Perivascular Adipose Tissue Inflammation: The Anti-Inflammatory Role of Ghrelin in Atherosclerosis Progression

Perivascular adipose tissue (PVAT) and its adipokines engage in bidirectional crosstalk with the vascular wall. Atherosclerosis disrupts this interaction through inflammation, rupture-prone plaques, subsequent thrombosis. The cardioprotective effects of ghrelin are contradiction to adipogenic properties. concurrent research anti-/pro-atherogenic mechanisms PVAT-derived provides a better understanding atherosclerosis progression metabolic disorders. In-depth coverage characteristic features PVAT concerning dysfunction, survey ghrelin-induced anti-inflammatory on macrophage infiltration inhibitory activity proinflammatory adipokine secretion, show that impact endothelial function should be studied relation PVAT.